The SimulTOF TWO is a linear bipolar MALDI-TOF mass spectrometer which provides high-speed molecular imaging of both small and large molecules in both positive and negative ion modes.

  • Performance for proteins and olignucleotides equivalent to SimulTOF ONE
  • Longer flight tube and programable voltages provide higher resolution for peptides and metabolites
  • Very high sensitivity, precision, and dynamic range for both positive and negative ions
  • Provides isotopic resolution below ca. 6 kDa, and isotopic envelope resolution for high masses

Example: Image of full porcine pancreas at 200 pixels/second showing Islets of Langerhans. Spatial Resolution is 10 mm with single laser shot/pixel.

Islets of Langerhans are irregularly shaped patches of endocrine tissue located within the pancreas of most vertebrates. They are named for the German physician Paul Langerhans, who first described them in 1869.

The islets of Langerhans contain alpha, beta, and delta cells that produce glucagon, insulin, and somatostatin, respectively. A fourth type of islet cell, the F (or PP) cell, is located at the periphery of the islets and secretes pancreatic polypeptide.